NanoVelcro CTC assay and Prostate Cancer (PC)
Our team utilized the NanoVelcro assay for prostate cancer circulating tumor cell (CTC) analysis. We focused on the morphological characteristics and molecular signatures of CTCs and associated the liquid biopsy results with clinical disease outcomes.
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Publications
1. Zhao Libo, Lu Yi-Tsung, Li Fuqiang, Wu Kui, Hou Shuang, Yu Juehua, Shen Qinglin, Wu Dongxia, Song Min, Ouyang Wei-Han, Luo Zheng, Lee Tom, Fang Xiaohong, Shao Chen, Xu Xun, Garcia Mitch A, Chung Leland W K, Rettig Matthew, Tseng Hsian-Rong, Posadas Edwin M High-Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber-Embedded Microchip for Whole Exome Sequencing. Advanced materials (Deerfield Beach, Fla.). 2013; 52(16):.
2. Lu Yi-Tsung, Zhao Libo, Shen Qinglin, Garcia Mitch A, Wu Dongxia, Hou Shuang, Song Min, Xu Xiaochun, Ouyang Wei-Han, Ouyang William W-L, Lichterman Jake, Luo Zheng, Xuan Xuan, Huang Jiaoti, Chung Leland W K, Rettig Matthew, Tseng Hsian-Rong, Shao Chen, Posadas Edwin M NanoVelcro Chip for CTC enumeration in prostate cancer patients. Methods (San Diego, Calif.). 2013; 64(2): 144-52.
3. Wang S, Liu K, Liu J, Yu ZT, Xu X, Zhao L, Lee T, Lee EK, Reiss J, Lee YK, Chung LW, Huang J, Rettig M, Seligson D, Duraiswamy KN, Shen CK, Tseng HR Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers. Angew Chem Int Ed Engl. 2011; 50(13): 3084-8.
4. Jiang Runze, Lu Yi-Tsung, Ho Hao, Li Bo, Chen Jie-Fu, Lin Millicent, Li Fuqiang, Wu Kui, Wu Hanjie, Lichterman Jake, Wan Haolei, Lu Chia-Lun, OuYang William, Ni Ming, Wang Linlin, Li Guibo, Lee Tom, Zhang Xiuqing, Yang Jonathan, Rettig Matthew, Chung Leland W K, Yang Huanming, Li Ker-Chau, Hou Yong, Tseng Hsian-Rong, Hou Shuang, Xu Xun, Wang Jun, Posadas Edwin M A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer. Oncotarget. 2015; 6(42): 44781-93.
5. Lin Millicent, Chen Jie-Fu, Lu Yi-Tsung, Zhang Yang, Song Jinzhao, Hou Shuang, Ke Zunfu, Tseng Hsian-Rong Nanostructure embedded microchips for detection, isolation, and characterization of circulating tumor cells. Accounts of chemical research. 2014; 47(10): 2941-50.
6. Chen Jie-Fu, Ho Hao, Lichterman Jake, Lu Yi-Tsung, Zhang Yang, Garcia Mitch A, Chen Shang-Fu, Liang An-Jou, Hodara Elisabeth, Zhau Haiyen E, Hou Shuang, Ahmed Rafi S, Luthringer Daniel J, Huang Jiaoti, Li Ker-Chau, Chung Leland W K, Ke Zunfu, Tseng Hsian-Rong, Posadas Edwin M Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases. Cancer. 2015; 121(18): 3240-51.
7. Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells
JF Chen, Y Zhu, YT Lu, E Hodara, S Hou, VG Agopian, JS Tomlinson.Theranostics 6 (9), 1425-1439, 2016
8. Applications of circulating tumor cells for prostate cancer S Cheng, JF Chen, YT Lu, LWK Chung, HR Tseng, EM Posadas
Asian journal of urology 3 (4), 254-259 4, 2016
9. Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection. MY Shen, JF Chen, CH Luo, S Lee, CH Li, YL Yang, YH Tsai, BC Ho, Advanced healthcare materials 7 (3), 1700701 2 2018
10. Circulating tumor cells in prostate cancer: beyond enumeration JF Chen, YT Lu, S Cheng, HR Tseng, RA Figlin, EM Posadas Clin Adv Hematol Oncol 15, 63-73 1 2017
11. A phase II study of cabozantinib in metastatic castration-resistant prostate cancer (mCRPC) with visceral metastases (VM) with very small nuclear circulating tumor cell (vsnCTC) association studies. R Huynh, JF Chen, M Tighiouart, M Sievert, A Oppenheim, NP Moldawer,Journal of Clinical Oncology 34 (2_suppl), 208-208 1 2016
12. Dynamic variations in gene expressions of circulating tumor cells in metastatic castration-resistant prostate cancer patients in response to androgen receptor signaling inhibitors. YJ Jan, S You, J Yoon, JF Chen, N Yao, S Cheng, M Freeman, HR Tseng, Journal of Clinical Oncology 36 (15_suppl), e17063-e17063 2018
13. NanoVelcro CTC purification systems for expressional analysis of circulating tumor cells from prostate cancer patients. YJ Jan, JF Chen, S You, N Yao, S Cheng, M Freeman, HR Tseng, Journal of Clinical Oncology 36 (6_suppl), 295-295 2018
14. Structure and function analysis in circulating tumor cells: using nanotechnology to study nuclear size in prostate cancer
N Yao, YJ Jan, S Cheng, JF Chen, LWK Chung, HR Tseng, EM Posadas American journal of clinical and experimental urology 6 (2), 43